July 13, 2018

PARP1 is up-regulated in Non-small cell lung cancer tissues in the presence of the cyanobacterial toxin microcystin

Front. Microbiol. | doi: 10.3389/fmicb.2018.01757

Patrick Apopa, Lisa Alley, Rosalind Penney, Konstantinos Arnaoutakis, Mathew Steliga, Susan Jeffus, Emine Bircan, Banu Gopalan, Jing Jin, Preecha Patumcharoenpol, Piroon Jenjaroenpun, Thidathip Wongsurawat, Nishi Shah, Gunnar Boysen, David Ussery, Intawat Nookaew, Pebbles Fagan, Gurkan Bebek, Mohammed Orloff

Abstract

Non-small cell lung cancer (NSCLC) is the major form of lung cancer, with adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being its major subtypes. Smoking alone cannot completely explain the lung cancer etiology. We hypothesize that altered lung microbiome and chronic inflammatory insults in lung tissues contribute to carcinogenesis. Here we explore the microbiome composition of LUAD samples, compared to LUSC and normal samples…

Read more: https://www.frontiersin.org/articles/10.3389/fmicb.2018.01757/abstract