February 14, 2018

Genome-Based Comparison of Clostidioides difficile: Average Amino Acid Identity Analysis of Core Genomes

Microb Ecol. 2018 Feb 14. | DOI: 10.1007/s00248-018-1155-7.

Cabal A, Jun SR, Jenjaroenpun P, Wanchai V, Nookaew I, Wongsurawat T, Burgess MJ, Kothari A, Wassenaar TM, Ussery DW


Infections due to Clostridioides difficile (previously known as Clostridium difficile) are a major problem in hospitals, where cases can be caused by community-acquired strains as well as by nosocomial spread. Whole genome sequences from clinical samples contain a lot of information but that needs to be analyzed and compared in such a way that the outcome is useful for clinicians or epidemiologists. Here, we compare 663 public available complete genome sequences of C. difficile using average amino acid identity (AAI) scores. This analysis revealed that most of these genomes (640, 96.5%) clearly belong…

Read more: https://www.ncbi.nlm.nih.gov/pubmed/29445826