May 18, 2018

Gene expression profile analysis of aortic vascular smooth muscle cells reveals upregulation of cadherin genes in myocardial infarction patients

Physiol Genomics. 2018 May 18. doi: 10.1152/physiolgenomics.00042.2017

Derda AA, Woo CC, Wongsurawat T, Richards M, Lee CN, Kofidis T, Kuznetsov VA, Sorokin VA

Abstract

Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of atherosclerotic plaques. To date, the expression patterns of cadherin have not been well investigated in MI aortic VSMCs. We aimed to investigate the expression of cadherin genes in the aortic wall of patients with and without MI. Laser capture microdissected VSMCs were obtained from aortic tissue samples of patients undergoing…

Read more: https://www.ncbi.nlm.nih.gov/pubmed/29775430