Publications


May 16, 2018

Microcephaly by Zika Virus in Thailand Emerging Infectious Diseases

Thidathip Wongsurawat, Niracha Athipanyasilp, Piroon Jenjaroenpun, Se-Ran Jun, Bualan Kaewnapan, Trudy M. Wassenaar, Nuttawut Leelahakorn, Nasikarn Angkasekwinai, Wannee Kantakamalakul, David W. Ussery, Ruengpung Sutthent, Intawat Nookaew, Navin Horthongkham Abstract We report a confirmed case of congenital Zika virus infection with microcephaly (CZVIM) caused by autochthonous infection at week 9 of pregnancy with Zika virus (ZIKV)…


May 2, 2018

DNAp: A Pipeline for DNA-seq Data Analysis

Scientific Reports (2018) volume 8, Article number: 6793  doi:10.1038/s41598-018-25022-6 Jason L. Causey, Cody Ashby, Karl Walker, Zhiping Paul Wang, Mary Yang, Yuanfang Guan, Jason H. Moore & Xiuzhen Huang ABSTRACT: Next-generation sequencing is empowering genetic disease research. However, it also brings significant challenges for efficient and effective sequencing data analysis. We built a pipeline, called…


May 1, 2018

A Review of Connectivity Map and Computational Approaches in Pharmacogenomics

Briefings in Bioinformatics, 19(3):506-523 | DOI: 10.1093/bib/bbw112 Musa A., Ghoraie L.S., Zhang S.,Glazko G., Yli-Harja O., Dehmer M., Haibe-Kains B., Emmert-Streib F. Abstract Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast…


April 17, 2018

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2103-2108. doi: 10.1016/j.bmcl.2018.04.035. Epub 2018 Apr 17 Boezio AA, Andrews K, Boezio C, Chu-Moyer M, Copeland KW, DiMauro EF, Foti RS, Fremeau RT Jr, Gao H, Geuns-Meyer S, Graceffa RF, Gunaydin H, Huang H, La DS, Ligutti J, Moyer BD, Peterson EA, Yu V, Weiss MM Abstract Recently, the…


March 23, 2018

Temporal Dynamics of Gut Microbiota in Triclocarban-Exposed Weaned Rats

Authors: Rebekah C. Kennedy, Russell R. Fling, Michael S. Robeson, Arnold M. Saxton, Liesel G. Schneider, John L. Darcy, David A. Bemis, Ling Zhao, Jiangang Chen ABSTRACT: Widely used as an antimicrobial in antibacterial bar soaps, triclocarban (3,4,4′-trichlorocarbanilide; TCC) is effective against Gram-positive bacteria but shows little efficacy against Gram-negative strains, potentially altering the composition…


The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate

Biotechnol Biofuels. 2018 Mar 23 | DOI: 10.1186/s13068-018-1076-1 Poudel S, Giannone RJ, Basen M, Nookaew I, Poole FL, Kelly RM, Adams MWW, Hettich RL Abstract Caldicellulosiruptor bescii is a thermophilic cellulolytic bacterium that efficiently deconstructs lignocellulosic biomass into sugars, which subsequently can be fermented into alcohols, such as ethanol, and other products. Deconstruction of complex substrates by C. bescii involves a…


Kinase domain activation through gene rearrangement in multiple myeloma

Leukemia. 2018 Mar 23. doi: 10.1038/s41375-018-0108-y Morgan GJ, He J, Tytarenko R, Patel P, Stephens OW, Zhong S, Deshpande S, Bauer M, Weinhold N, Schinke C, Rasche L, Bailey M, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Zangari M, van Rhee F, Mughal T, Davies FE, Walker BA Abstract Chromosomal rearrangements that…


March 16, 2018

Modeling the Personal Health Ecosystem

Stud Health Technology Informatics. 2018;249:38-49 Blobel B, Brochhausen, Ruotsalainen P. Abstract Complex ecosystems like the pHealth one combine different domains represented by a huge variety of different actors (human beings, organizations, devices, applications, components) belonging to different policy domains, coming from different disciplines, deploying different methodologies, terminologies, and ontologies, offering different levels of knowledge, skills,…


March 7, 2018

UAMS Team First to Add Directly Sequenced RNA to Public Database

A group of UAMS researchers is the first to deposit directly sequenced RNA to the National Center for Biotechnology Information databases, made possible by their utilization of a novel, handheld genetic sequencing technology. The federal government maintains a collection of databases with the aim of advancing science and health by providing public access to biomedical…


February 14, 2018

Genome-Based Comparison of Clostidioides difficile: Average Amino Acid Identity Analysis of Core Genomes

Microb Ecol. 2018 Feb 14. | DOI: 10.1007/s00248-018-1155-7. Cabal A, Jun SR, Jenjaroenpun P, Wanchai V, Nookaew I, Wongsurawat T, Burgess MJ, Kothari A, Wassenaar TM, Ussery DW Abstract Infections due to Clostridioides difficile (previously known as Clostridium difficile) are a major problem in hospitals, where cases can be caused by community-acquired strains as well as…



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