July 13, 2018

PARP1 is up-regulated in Non-small cell lung cancer tissues in the presence of the cyanobacterial toxin microcystin

Front. Microbiol. | doi: 10.3389/fmicb.2018.01757 Patrick Apopa, Lisa Alley, Rosalind Penney, Konstantinos Arnaoutakis, Mathew Steliga, Susan Jeffus, Emine Bircan, Banu Gopalan, Jing Jin, Preecha Patumcharoenpol, Piroon Jenjaroenpun, Thidathip Wongsurawat, Nishi Shah, Gunnar Boysen, David Ussery, Intawat Nookaew, Pebbles Fagan, Gurkan Bebek, Mohammed Orloff Abstract Non-small cell lung cancer (NSCLC) is the major form of lung…

June 18, 2018

Highly accurate model for prediction of lung nodule malignancy with CT scans

Scientific Reports, Nature. volume 8, Article number: 9286 (2018) Jason L. Causey, Junyu Zhang, Shiqian Ma, Bo Jiang, Jake A. Qualls, David G. Politte, Fred Prior, Shuzhong Zhang, Xiuzhen Huang Abstract Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for…

June 17, 2018

E. coli and colorectal cancer, a complex relationship that deserves a critical mindset

Crit Rev Microbiol. 2018 Jun 17:1-14. doi: 10.1080/1040841X.2018.1481013 Trudy M. Wassenaar Abstract To the multiple factors that may eventually result in colorectal cancer (CRC), strains of E. coli have now been added, in particular strains producing colibactin from their polyketide synthesis (pks) locus. The evidence and mechanistic explanations for this unfortunate effect of what is in…

June 15, 2018

Reengineering Workflow for Curation of DICOM Datasets

J Digital Imaging (15 Jun 2018). https://doi.org/10.1007/s10278-018-0097-4 William Bennett, Kirk Smith, Quasar Jarosz, Tracy Nolan, Walter Bosch Abstract Reusable, publicly available data is a pillar of open science and rapid advancement of cancer imaging research. Sharing data from completed research studies not only saves research dollars required to collect data, but also helps insure that…

June 8, 2018

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Blood. 2018 Jun 8. pii: blood-2018-03-840132. doi: 10.1182/blood-2018-03-840132 Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat…

May 18, 2018

Gene expression profile analysis of aortic vascular smooth muscle cells reveals upregulation of cadherin genes in myocardial infarction patients

Physiol Genomics. 2018 May 18. doi: 10.1152/physiolgenomics.00042.2017 Derda AA, Woo CC, Wongsurawat T, Richards M, Lee CN, Kofidis T, Kuznetsov VA, Sorokin VA Abstract Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture….

May 16, 2018

Microcephaly by Zika Virus in Thailand Emerging Infectious Diseases

Thidathip Wongsurawat, Niracha Athipanyasilp, Piroon Jenjaroenpun, Se-Ran Jun, Bualan Kaewnapan, Trudy M. Wassenaar, Nuttawut Leelahakorn, Nasikarn Angkasekwinai, Wannee Kantakamalakul, David W. Ussery, Ruengpung Sutthent, Intawat Nookaew, Navin Horthongkham Abstract We report a confirmed case of congenital Zika virus infection with microcephaly (CZVIM) caused by autochthonous infection at week 9 of pregnancy with Zika virus (ZIKV)…

May 2, 2018

DNAp: A Pipeline for DNA-seq Data Analysis

Scientific Reports (2018) volume 8, Article number: 6793  doi:10.1038/s41598-018-25022-6 Jason L. Causey, Cody Ashby, Karl Walker, Zhiping Paul Wang, Mary Yang, Yuanfang Guan, Jason H. Moore & Xiuzhen Huang ABSTRACT: Next-generation sequencing is empowering genetic disease research. However, it also brings significant challenges for efficient and effective sequencing data analysis. We built a pipeline, called…

May 1, 2018

A Review of Connectivity Map and Computational Approaches in Pharmacogenomics

Briefings in Bioinformatics, 19(3):506-523 | DOI: 10.1093/bib/bbw112 Musa A., Ghoraie L.S., Zhang S.,Glazko G., Yli-Harja O., Dehmer M., Haibe-Kains B., Emmert-Streib F. Abstract Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast…

April 17, 2018

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2103-2108. doi: 10.1016/j.bmcl.2018.04.035. Epub 2018 Apr 17 Boezio AA, Andrews K, Boezio C, Chu-Moyer M, Copeland KW, DiMauro EF, Foti RS, Fremeau RT Jr, Gao H, Geuns-Meyer S, Graceffa RF, Gunaydin H, Huang H, La DS, Ligutti J, Moyer BD, Peterson EA, Yu V, Weiss MM Abstract Recently, the…

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