September 4, 2018

Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy

Grossberg AJ1,2, Mohamed ASR1,3, Elhalawani H1, Bennett WC4, Smith KE4, Nolan TS4, Williams B1, Chamchod S1,5, Heukelom J1,6, Kantor ME1, Browne T1, Hutcheson KA7, Gunn GB1, Garden AS1, Morrison WH1, Frank SJ1, Rosenthal DI1, Freymann JB8, Fuller CD1. Erratum in Author Correction: Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy. [Sci Data. 2018] Abstract Cross sectional imaging is essential for the patient-specific planning and delivery of…

September 1, 2018

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells

McCormick JJ1, VanDusseldorp TA1,2, Ulrich CG1, Lanphere RL3, Dokladny K4, Mosely PL5, Mermier CM1. Abstract Autophagy is a lysosome degradation pathway through which damaged organelles and macromolecules are degraded within the cell. A decrease in activity of the autophagic process has been linked to several age-associated pathologies, including triglyceride accumulation, mitochondrial dysfunction, muscle degeneration, and cardiac malfunction. Here, we examined the…

August 16, 2018

Gene Expression Differences in Pediatric Lymphatic Malformations: Size Really Matters

Gomez-Acevedo H1, Dornhoffer JR2, Stone A3,4, Dai Y5, Richter GT6,7. Abstract Lymphatic malformations (LMs) are congenital vascular anomalies characterized by dilated and cystic lymphatic channels. They are subdivided into macrocystic and microcystic lesions based upon the predominant size of the cysts involved. However, significant differences in clinical characteristics, treatment outcomes, and prognosis between macrocytic and microcytic disease suggest variation…

August 6, 2018

PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin

Apopa PL1, Alley L1, Penney RB2, Arnaoutakis K3, Steliga MA3, Jeffus S4, Bircan E1, Gopalan B5, Jin J1, Patumcharoenpol P6, Jenjaroenpun P6, Wongsurawat T6, Shah N7, Boysen G2, Ussery D6, Nookaew I6, Fagan P8, Bebek G9,10,11, Orloff MS1,3. Abstract Non-small cell lung cancer (NSCLC) is the major form of lung cancer, with adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being its major subtypes. Smoking alone cannot completely explain the lung cancer etiology. We…

July 18, 2018

Conservation of Two-Component Signal Transduction Systems in E. coli, Salmonella, and Across 100,000 Bacteria of Various Bacterial Phyla

Trudy M. Wassenaar, Visanu Wanchai, Duah Alkam, Intawat Nookaew, David W. Ussery Chapter 7 in Molecular Mechanisms of Microbial Evolution, P. H. Rampelotto (ed.); Springer International Publishing AG, part of Springer Nature 2018Grand Challenges in Biology and Biotechnology,

Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model

AJP-Endocrinology and Metabolism, in the press, July 2018 Brian Piccolo, James Graham, Kimber Stanhope, Intawat Nookaew, Kelly Mecer, Sree Chintapalli, Umesh Wankhade, Kartik Shankar, Peter Havel, Sean Adams Abstract Many factors contribute to, or can modify, the development of diseases such as obesity and type 2 diabetes, including the naturally occurring bacteria residing in the…

Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy

Scientific Data at Nature (2018) Aaron Grossberg, Abdallah Sherif Radwan Mohamed, Hesham Elhalawani, William Bennett, Kirk Smith, Tracy Nolan, Bowman Williams, Sasikarn Chamchod, Jolien Heukelom, Michael Kantor, Theodora Browne, Katherine Hutcheson, G Brandon Gunn, Adam Garden, William Morrison, Steven Frank, David Rosenthal, John Freymann, Clifton Fuller

Protocol for the Analysis of Laser Capture Microdissected Fresh-Frozen Tissue Homogenates by Silver-Stained 1D SDS-PAGE

Methods Mol Biol. 2018;1723:95-110. doi: 10.1007/978-1-4939-7558-7_4. Prieto DA, Whitely G, Johann DJ Jr, Blonder J Abstract The heterogeneity present in solid tumors adds significant difficulty to scientific analysis and improved understanding. Fundamentally, solid tumor formation consists of cancer cells proper along with stromal elements. The burgeoning malignant process is dependent upon modified stromal elements. Collectively,…

July 17, 2018

Diabetes-Associated Alterations in the Cecal Microbiome and Metabolome are Independent of Diet or Environment in the UC Davis Type 2-Diabetes Mellitus Rat Model

Piccolo BD1, Graham JL2, Stanhope KL3, Nookaew I4, Mercer KE5, Chintapalli SV6, Wankhade UD7, Shankar K8, Havel PJ9, Adams SH1. Abstract The composition of the gut microbiome is altered in obesity and type 2 diabetes; however, it is not known whether these alterations are mediated by dietary factors or related to declines in metabolic health. To address this, cecal contents were collected from age-matched,…

July 13, 2018

PARP1 is up-regulated in Non-small cell lung cancer tissues in the presence of the cyanobacterial toxin microcystin

Front. Microbiol. | doi: 10.3389/fmicb.2018.01757 Patrick Apopa, Lisa Alley, Rosalind Penney, Konstantinos Arnaoutakis, Mathew Steliga, Susan Jeffus, Emine Bircan, Banu Gopalan, Jing Jin, Preecha Patumcharoenpol, Piroon Jenjaroenpun, Thidathip Wongsurawat, Nishi Shah, Gunnar Boysen, David Ussery, Intawat Nookaew, Pebbles Fagan, Gurkan Bebek, Mohammed Orloff Abstract Non-small cell lung cancer (NSCLC) is the major form of lung…

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